Valproic acid
Valproic acid is a carboxylic acid that increases gamma-amino butyric acid (GABA) levels in the central nervous system and inhibits the enzyme histone deacetylase 1 (HDAC1). [#] [#]
View ArticlePoly(I)-Poly(C12U)
Poly(I)-poly (C12U), a specifically mismatched double stranded RNA (dsRNA) nucleic compound, is a biological response modifier with anti-HIV activity. [#]
View ArticleCobicistat
Cobicistat (COBI), also known as GS-9350, is a specific, potent, mechanism-based inhibitor of cytochrome P450 3A (CYP3A) enzymes that lacks antiretroviral activity.[#][#]
View ArticleBevirimat
Bevirimat, also known as PA-457, is a betulinic acid derivative and a first-in-its-class maturation inhibitor. It is in Phase II studies to determine its use as a treatment for HIV and has been...
View ArticleRacivir
Racivir, also known as RCV, is an oxothiolane nucleoside reverse transcriptase inhibitor similar to emtricitabine and lamivudine. [#] Racivir is a 50:50 mixture of emtricitabine and its positive...
View ArticleKP-1461
KP-1461 is a potent, non--chain-terminating, mutagenic deoxyribonucleoside analogue. Designated a DNA covert nucleoside, the drug consists of a modified base that incorporates randomly into HIV and...
View ArticleFosalvudine
Fosalvudine, also known as fosalvudine tidoxil, is a prodrug of alovudine, a nucleoside reverse transcriptase inhibitor. [#]
View ArticleElvucitabine
Elvucitabine, also known as ELV, ACH-126443, L-Fd4C or beta-L-Fd4C, is an L-cytosine nucleoside analogue of stavudine with potent activity against HIV and chronic hepatitis B. [#] [#]
View ArticleApricitabine
Apricitabine, previously known as AVX754 and SPD754, is a nucleoside reverse transcriptase inhibitor (NRTI). Apricitabine is the negative enantiomer of a member of the 4-thio heterosubstituted...
View ArticleUC-781
UC-781 is a thiocarboxanilide non-nucleoside reverse transcriptase inhibitor (NNRTI). [#]
View ArticleTenofovir
Tenofovir is an adenosine nucleoside monophosphate reverse transcriptase inhibitor and viral replication inhibitor. [#]
View ArticleSPL7013
SPL7013 is a lysine-based dendrimer with naphthalene disulfonic acid surface groups. [#] It is the active ingredient of VivaGel, a water-based vaginal microbicide gel. [#]
View ArticlePRO 2000
PRO 2000 is a synthetic, long-chain, naphthalene sulfonic acid polymer. The polymer is polyanionic and consists of alternating 2-naphthalene sulfonic acid sodium salt and methylene units. [#] [#]
View ArticleHydroxyethyl cellulose
Hydroxyethyl cellulose (HEC) is a nonionic, water-soluble polymer that can thicken, suspend, bind, emulsify, form films, stabilize, disperse, retain water, and provide protective colloid action. [#]
View ArticleCyanovirin-N
Cyanovirin-N, also known as CV-N, is a protein from the cyanobacterium Nostoc ellipsosporum (blue-green algae). The protein exists as either a quasi-symmetric, two-domain monomer or a domain-swapped...
View ArticleCellulose sulfate
Cellulose sulfate, also known as CS, is a high molecular weight carboxymethylcellulose-based polymer. [#] It is a noncytotoxic, antifertility agent that exhibits in vitro antimicrobial activity against...
View ArticleCarrageenan
Carrageenan is a water-soluble mixture of sulfated polysaccharides extracted from red seaweed (Rhodophyceae), or Irish moss, found off the Atlantic coasts. [#] [#] The kappa, iota, and lambda forms of...
View ArticleCarbomer 974
Carbomer 974 is a water-based, detergent-free, buffering agent that contributes to the acidic buffering action of BufferGel, an investigational microbicide and spermicide gel. [#] Carbomer 974, a...
View ArticleBMS-378806
BMS-378806, or BMS-806, is a small molecule entry inhibitor of HIV-1 that targets the viral envelope protein. [#] [#]
View ArticleElvitegravir
Elvitegravir (EVG), also known as GS 9137, is a low-molecular-weight, highly selective integrase inhibitor that shares the core structure of quinolone antibiotics. [#] Integrase inhibitors are a new...
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